21 اکتبر 2025, مقالات ISI
Oxidative stress results from an imbalance between reactive oxygen species production and antioxidant defense mechanisms, contributing to various chronic diseases. Walnuts (Juglans regia L.), rich in polyphenolic compounds, may help reduce oxidative stress. This study systematically reviewed and quantitatively analyzed randomized controlled trials (RCTs) to evaluate the effects of walnut consumption on biomarkers of oxidative stress.
PubMed, Scopus, Embase, and Web of Science databases were searched up to November 30, 2024. Eligible RCTs assessing walnut intake and oxidative stress biomarkers were included. A random-effects meta-analysis was conducted to estimate pooled weighted mean differences (WMD) and 95% confidence intervals (CIs).
Four RCTs were included. Pooled analysis indicated that walnut consumption significantly increased catalase (CAT) activity (WMD: 42.20; 95% CI: 34.28, 50.11; p < 0.001). However, no significant effects were observed on reduced glutathione (GSH), oxidized glutathione (GSSG), lipid peroxidation (LPO), or oxygen radical absorbance capacity (ORAC).
Walnut consumption enhances catalase activity but does not significantly alter other oxidative stress biomarkers. While walnuts may exert mild antioxidant effects, further high-quality, large-scale trials are warranted to confirm these findings.
Walnut; Oxidative stress; Catalase; Antioxidant biomarkers; Meta-analysis; Systematic review.
Ginseng supplementation may improve inflammatory profiles and support cardiometabolic health, according to a comprehensive review of 44 randomized controlled trials.
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Curcumin supplementation appears to alleviate anxiety symptoms, but more high-quality trials are needed to confirm its clinical effectiveness.
Ghee may support bone and joint health through fatty acids and vitamins that reduce inflammation, enhance bone density, and improve joint lubrication.
Glucomannan supplementation reduces total cholesterol and LDL-C in adults, with no significant effects on TG, HDL-C, or Apo A1 levels
Berberine supplementation shows significant benefits in improving lipid profile (reducing LDL-C, TC, TG, and increasing HDL-C) and waist circumference, though its effects on overall obesity indices remain inconclusive.
An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine
A scientific report on a novel herbal cream for skin wound healing, combining traditional Persian botanical knowledge with modern pharmaceutical research.
This umbrella and systematic review with meta-analysis evaluates the efficacy and safety of imeglimin for type 2 diabetes, showing significant improvements in glycemic control and beta-cell function.
