Blog > The effect of ginseng supplementation and health outcomes: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials

Oct. 1, 2025, مقالات ISI

The effect of ginseng supplementation and health outcomes: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials


Abstract

Background

Ginseng, a widely used herbal remedy, has been proposed to possess cardiometabolic benefits. However, findings regarding its effects on health outcomes remain inconsistent.


Methods

This meta-analysis included 44 randomized controlled trials (RCTs) covering 56 intervention arms, aiming to evaluate the impact of ginseng supplementation across various health parameters using a comprehensive literature search.


Results

Ginseng supplementation significantly reduced IL-6 levels (WMD = -2.03 pg/mL; 95% CI: -3.12 to -0.93; p < 0.001). No significant effects were observed on body weight, BMI, waist circumference, blood pressure, or lipid profile. Sensitivity analyses revealed potential blood pressure benefits.


Conclusions

Ginseng may improve inflammatory markers such as IL-6 and adiponectin but appears to have no substantial effects on anthropometric indices or lipid levels. Further long-term, well-designed trials are warranted.



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